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Clinical trials in Prague – page 62

1 218 clinical trials in Prague, Czechia across 18 research sites. Every trial is listed in the EU Clinical Trials Register and updated daily.

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Prague at a glance
1 218
clinical trials
  • Research sites18
Type of trial
Recruitment status
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1 218 trials in Prague

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Study on Itepekimab for Adults with Chronic Rhinosinusitis and Nasal Polyps

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Itepekimab
  • Sponsor:Sanofi-Aventis Recherche & Developpement

Parkinson's disease

Not recruiting

Study of CVN424 for Reducing Motor Complications in Parkinson's Disease Patients

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:1-[2-[4-(2,4-DIFLUOROPHENOXY)PIPERIDIN-1-YL]-3-[[(3R)-OXOLAN-3-YL]AMINO]-7,8-DIHYDRO-5H-PYRIDO[3,4-B]PYRAZIN-6-YL]ETHANONE
  • Sponsor:Cerevance Beta Inc.

Glioblastoma

Not recruiting

Study on the Effectiveness of Optune with Temozolomide and Pembrolizumab in Patients with Newly Diagnosed Glioblastoma

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Pembrolizumab
  • Sponsor:Novocure GmbH

Crohn's disease

Not recruiting

Study of SAR441566 compared to placebo for adults with moderate to severe Crohn's disease

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Sponsor:Sanofi-Aventis Recherche & Developpement

Acute kidney injury

Not recruiting

Study of GDC-8264 compared to placebo for preventing kidney injury in patients at risk of acute kidney injury after heart surgery

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:RO7288817
  • Sponsor:Genentech Inc.

Skin ulcer

Not recruiting

Study on the Effectiveness of Allo-APZ2-CVU for Patients with Long-Term, Non-Healing Venous Leg Ulcers

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Allogeneic skin-derived ABCB5-POSITIVE dermal mesenchymal stromal cells
  • Sponsor:Rheacell GmbH & Co. KG

Study Comparing Elacestrant and Standard Endocrine Therapy for Patients with Early Breast Cancer at High Risk of Recurrence

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Anastrozole
  • Sponsor:Stemline Therapeutics Inc.

Obesity+1

Not recruiting

Study on the Effectiveness of Orforglipron for Patients with Obstructive Sleep Apnea and Obesity or Overweight

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:3-((1S,2S)-1-(5-((S)-2,2-Dimethyltetrahydro-2H-Pyran-4-Yl)-2-((S)-3-(3-(4-Fluoro-1-Methyl-1H-Indazol-5-Yl)-2-Oxo-2,3-Dihydro-1H-Imidazol-1-Yl)-2-(4-Fluoro-3,5-Dimethylphenyl)-4-Methyl-4,5,6,7-Tetrahydro-2H-Pyrazolo[4,3-C]Pyridine-5-Carbonyl)-1H-Indol-1-Yl)-2-Methylcyclopropyl)-5-Oxo-1,2,4-Oxadiazol-4-Ide Hemicalcium
  • Sponsor:Eli Lilly & Co.

Study on the Effects of MM120 (Lysergide) for Adults with Generalized Anxiety Disorder

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Lysergide
  • Sponsor:Definium Therapeutics US Inc.

Migraine

Not recruiting

Study on Atogepant for Preventing Menstrual Migraine in Women

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years
  • Substances:Atogepant
  • Sponsor:AbbVie Deutschland GmbH & Co. KG

Study on the Safety and Effectiveness of ALPHA1H for Adults with Non-Muscle Invasive Bladder Cancer Awaiting Tumor Removal Surgery

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:ALPHA1H
  • Sponsor:Hamlet BioPharma AB

Study of Quizartinib with Chemotherapy for Adults with Newly Diagnosed FLT3-ITD Negative Acute Myeloid Leukemia

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Cytarabine
  • Sponsor:Daiichi Sankyo Inc.

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Clinical research in Prague

What the registry says about research in the country

01 Neoplasms and Oncology

Clinical trial activity in Praha includes research in advanced melanoma and diffuse large B-cell lymphoma, with a strong focus on improving cancer control and extending survival.

  • Advanced melanoma
  • Previously untreated diffuse large B-cell lymphoma
  • Testing new treatment combinations
  • Evaluating survival outcomes and disease progression

These studies are designed to refine how immunotherapy and other cancer treatments perform in everyday clinical care.

02 Cardiovascular Diseases

Research in cardiovascular diseases is centered on reducing major heart and vascular events, with trials looking at hypertension, atherosclerotic cardiovascular disease, and heart failure prevention.

  • Hypertension
  • Atherosclerotic cardiovascular disease
  • Prevention of heart failure
  • Lowering the risk of stroke and other vascular complications

Several studies aim to improve treatment effectiveness for patients at elevated cardiovascular risk.

03 Respiratory Tract Diseases

Trials in the respiratory field focus on better symptom control and fewer flare-ups in chronic obstructive pulmonary disease, alongside ongoing work in infection-related lung illness.

  • Chronic obstructive pulmonary disease
  • Covid-19 in people at high risk of severe illness
  • Testing new antiviral and anti-inflammatory approaches
  • Reducing exacerbations and severe outcomes

These studies support more effective care for both chronic and acute respiratory conditions.

04 Skin and Connective Tissue Diseases

Dermatology research in Czechia includes several inflammatory skin disorders, with studies targeting itch, lesion control, and long-term disease management.

  • Atopic dermatitis
  • Moderate to severe plaque psoriasis
  • Hidradenitis suppurativa
  • Neurodermatitis and lichen simplex chronicus

The goal is to evaluate new therapies that may ease symptoms and improve quality of life.

05 Immune System Diseases

Studies in immune-mediated disease are exploring treatments that can calm abnormal inflammation while maintaining safety and tolerability.

  • Psoriatic arthritis
  • Atopic dermatitis
  • Psoriasis-related inflammatory conditions
  • Assessing immune-targeted therapy effectiveness

These trials aim to improve control of chronic immune-driven disease burden.

06 Nervous System Diseases

Neurology-related research focuses on agitation in Alzheimer's disease dementia, with efforts to better manage behavioral symptoms that affect patients and caregivers.

  • Agitation in Alzheimer's disease dementia
  • Symptom relief and behavioral improvement
  • Evaluating new therapeutic options

These studies may help support more practical care for people living with dementia.

07 Nutritional and Metabolic Diseases

Metabolic research in Praha includes trials for overweight, obesity, and related conditions, often linked with cardiovascular risk.

  • Overweight and obesity
  • Hypertension with obesity
  • Type 2 diabetes-related weight management
  • Supporting weight loss and cardiometabolic health

These studies are testing approaches that may help reduce long-term health risks tied to excess weight.

08 Virus Diseases

In the area of virus diseases, research is centered on improving treatment options for people with COVID-19 who are at higher risk of becoming seriously ill.

  • COVID-19 at high risk of progression
  • Reducing illness severity
  • Testing antiviral treatment effectiveness

The main aim is to help prevent worsening disease and support faster recovery.

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