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Clinical trials in Prague – page 93

1 218 clinical trials in Prague, Czechia across 18 research sites. Every trial is listed in the EU Clinical Trials Register and updated daily.

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Prague at a glance
1 218
clinical trials
  • Research sites18
Type of trial
Recruitment status
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1 218 trials in Prague

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Neoplasm malignant+2

Not recruiting

Study on Larotrectinib for Treating Children with Advanced Solid Tumors with NTRK Fusion

InvestigationalNo placebo
Countries:CzechiaCzechia
  • Participants:0–17 years · 18–64 years
  • Substances:Larotrectinib Sulfate
  • Sponsor:Bayer AG

Cervix carcinoma

Not recruiting

Study Comparing Tisotumab Vedotin with Chemotherapy for Patients with Recurrent or Metastatic Cervical Cancer

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Brimonidine Tartrate
  • Sponsor:Seagen Inc.

Asthma+1

Not recruiting

Study on the Effects and Safety of Dupilumab for Children Aged 2 to Under 6 with Uncontrolled Asthma or Severe Asthmatic Wheeze

Registered drug
Countries:CzechiaCzechia
  • Participants:0–17 years
  • Substances:Budesonide
  • Sponsor:Sanofi-Aventis Recherche & Developpement

Study of Adagrasib and Cetuximab for Patients with Advanced Colorectal Cancer with KRAS G12C Mutation After First-Line Therapy

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Adagrasib
  • Sponsor:Mirati Therapeutics Inc.

Study on Venetoclax and Azacitidine for Patients Newly Diagnosed with Higher-Risk Myelodysplastic Syndrome

Registered drug
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Azacitidine
  • Sponsor:AbbVie Deutschland GmbH & Co. KG

Study Comparing Relatlimab-Nivolumab Combination with Regorafenib or Trifluridine-Tipiracil for Patients with Advanced Metastatic Colorectal Cancer

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Nivolumab
  • Sponsor:Bristol Myers Squibb International Corporation

Endometrial cancer

Not recruiting

Study Comparing Pembrolizumab and Chemotherapy for Patients with Advanced or Recurrent Endometrial Cancer

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Carboplatin
  • Sponsor:Merck Sharp & Dohme LLC

Bladder cancer

Not recruiting

Study Comparing Enfortumab Vedotin and Pembrolizumab with Chemotherapy for Patients with Muscle-Invasive Bladder Cancer

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Cisplatin
  • Sponsor:Merck Sharp & Dohme LLC

Study Comparing SGN-B6A and Docetaxel for Adults with Previously Treated Non-Small Cell Lung Cancer

Registered drugNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Docetaxel
  • Sponsor:Seagen Inc.

Psoriasis

Not recruiting

Study on the Effectiveness and Safety of SAR441566 for Adults with Moderate to Severe Plaque Psoriasis

Investigational
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:SAR441566
  • Sponsor:Sanofi-Aventis Recherche & Developpement

Study on Frexalimab for Preserving Insulin Production in Newly Diagnosed Type 1 Diabetes Patients Aged 12-21 on Insulin Therapy

Registered drug
Countries:CzechiaCzechia
  • Participants:0–17 years · 18–64 years
  • Sponsor:Sanofi-Aventis Recherche & Developpement

Migraine+2

Not recruiting

Study on Long-Term Safety of Atogepant for Preventing Migraine in Patients with Chronic or Episodic Migraine

InvestigationalNo placebo
Countries:CzechiaCzechia
  • Participants:18–64 years · 65+ years
  • Substances:Atogepant
  • Sponsor:AbbVie Deutschland GmbH & Co. KG

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Clinical research in Prague

What the registry says about research in the country

01 Neoplasms and Oncology

Clinical trial activity in Praha includes research in advanced melanoma and diffuse large B-cell lymphoma, with a strong focus on improving cancer control and extending survival.

  • Advanced melanoma
  • Previously untreated diffuse large B-cell lymphoma
  • Testing new treatment combinations
  • Evaluating survival outcomes and disease progression

These studies are designed to refine how immunotherapy and other cancer treatments perform in everyday clinical care.

02 Cardiovascular Diseases

Research in cardiovascular diseases is centered on reducing major heart and vascular events, with trials looking at hypertension, atherosclerotic cardiovascular disease, and heart failure prevention.

  • Hypertension
  • Atherosclerotic cardiovascular disease
  • Prevention of heart failure
  • Lowering the risk of stroke and other vascular complications

Several studies aim to improve treatment effectiveness for patients at elevated cardiovascular risk.

03 Respiratory Tract Diseases

Trials in the respiratory field focus on better symptom control and fewer flare-ups in chronic obstructive pulmonary disease, alongside ongoing work in infection-related lung illness.

  • Chronic obstructive pulmonary disease
  • Covid-19 in people at high risk of severe illness
  • Testing new antiviral and anti-inflammatory approaches
  • Reducing exacerbations and severe outcomes

These studies support more effective care for both chronic and acute respiratory conditions.

04 Skin and Connective Tissue Diseases

Dermatology research in Czechia includes several inflammatory skin disorders, with studies targeting itch, lesion control, and long-term disease management.

  • Atopic dermatitis
  • Moderate to severe plaque psoriasis
  • Hidradenitis suppurativa
  • Neurodermatitis and lichen simplex chronicus

The goal is to evaluate new therapies that may ease symptoms and improve quality of life.

05 Immune System Diseases

Studies in immune-mediated disease are exploring treatments that can calm abnormal inflammation while maintaining safety and tolerability.

  • Psoriatic arthritis
  • Atopic dermatitis
  • Psoriasis-related inflammatory conditions
  • Assessing immune-targeted therapy effectiveness

These trials aim to improve control of chronic immune-driven disease burden.

06 Nervous System Diseases

Neurology-related research focuses on agitation in Alzheimer's disease dementia, with efforts to better manage behavioral symptoms that affect patients and caregivers.

  • Agitation in Alzheimer's disease dementia
  • Symptom relief and behavioral improvement
  • Evaluating new therapeutic options

These studies may help support more practical care for people living with dementia.

07 Nutritional and Metabolic Diseases

Metabolic research in Praha includes trials for overweight, obesity, and related conditions, often linked with cardiovascular risk.

  • Overweight and obesity
  • Hypertension with obesity
  • Type 2 diabetes-related weight management
  • Supporting weight loss and cardiometabolic health

These studies are testing approaches that may help reduce long-term health risks tied to excess weight.

08 Virus Diseases

In the area of virus diseases, research is centered on improving treatment options for people with COVID-19 who are at higher risk of becoming seriously ill.

  • COVID-19 at high risk of progression
  • Reducing illness severity
  • Testing antiviral treatment effectiveness

The main aim is to help prevent worsening disease and support faster recovery.

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