Clinical trials in Zwolle – page 4

197 clinical trials in Zwolle, The Netherlands across 4 research sites. Every trial is listed in the EU Clinical Trials Register and updated daily.

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197

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197 trials in Zwolle

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Ischaemic stroke

Recruiting

Study of alteplase and tenecteplase for intravenous thrombolysis in patients with ischemic stroke who are taking direct oral anticoagulants

Registered drugNo placebo

Study of alteplase and tenecteplase for intravenous thrombolysis in patients with ischemic stroke who are taking direct oral anticoagulants

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Alteplase
Sponsor:Insel Gruppe AG

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Arteriosclerosis

Recruiting

Long-term safety study of pelacarsen in patients with atherosclerotic cardiovascular disease who completed the Lp(a)HORIZON trial

InvestigationalNo placebo

Long-term safety study of pelacarsen in patients with atherosclerotic cardiovascular disease who completed the Lp(a)HORIZON trial

InvestigationalNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Pelacarsen
Sponsor:Novartis Pharma AG

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Dementia Alzheimer's type

Recruiting

Study of MK-2214 to slow disease progression in people with early Alzheimer's disease

Investigational

Study of MK-2214 to slow disease progression in people with early Alzheimer's disease

Investigational

The Netherlands

Participants:18–64 years · 65+ years
Substances:Florquinitau (18F)
Sponsor:Merck Sharp & Dohme LLC

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Axial spondyloarthritis+3

Recruiting

Study of Janus kinase inhibitor dose reduction in patients with rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis who have achieved low disease activity

Registered drugNo placebo

Study of Janus kinase inhibitor dose reduction in patients with rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis who have achieved low disease activity

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Baricitinib
Sponsor:Sint Maartenskliniek

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Malignant melanoma

Recruiting

Study to Evaluate IOpener-Melanoma Test for Predicting Response to Immunotherapy in Stage III or IV Skin Melanoma Patients

Registered drugNo placebo

Study to Evaluate IOpener-Melanoma Test for Predicting Response to Immunotherapy in Stage III or IV Skin Melanoma Patients

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Nivolumab
Sponsor:Leids Universitair Medisch Centrum (LUMC)

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Pancreatic carcinoma

Recruiting

Evaluation of Hydrocortisone, Octreotide, and Teres Ligament Patch Combination to Prevent Complications After Pancreatoduodenectomy in Patients with Pancreatic Head Cancer or IPMN

Registered drugNo placebo

Evaluation of Hydrocortisone, Octreotide, and Teres Ligament Patch Combination to Prevent Complications After Pancreatoduodenectomy in Patients with Pancreatic Head Cancer or IPMN

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Hydrocortisone
Sponsor:Amsterdam UMC Stichting

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Cardiac failure

Recruiting

Evaluating the Effect of Vicadrostat and Empagliflozin Combination Compared to Empagliflozin Alone in Patients with Heart Failure and Reduced Left Ventricular Function

Registered drug

Evaluating the Effect of Vicadrostat and Empagliflozin Combination Compared to Empagliflozin Alone in Patients with Heart Failure and Reduced Left Ventricular Function

Registered drug

The Netherlands

Participants:18–64 years · 65+ years
Substances:Bi 690517
Sponsor:Boehringer Ingelheim International GmbH

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Non-small cell lung cancer

Recruiting

Study of Sigvotatug Vedotin and Pembrolizumab for Patients with Advanced Non-Small Cell Lung Cancer with High PD-L1 Levels

Registered drugNo placebo

Study of Sigvotatug Vedotin and Pembrolizumab for Patients with Advanced Non-Small Cell Lung Cancer with High PD-L1 Levels

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Pembrolizumab
Sponsor:Pfizer Inc.

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Colorectal cancer

Recruiting

Study on the Safety and Effectiveness of Volrustomig with FOLFIRI and Bevacizumab for Colorectal Cancer Patients Without Liver Metastases

Registered drugNo placebo

Study on the Safety and Effectiveness of Volrustomig with FOLFIRI and Bevacizumab for Colorectal Cancer Patients Without Liver Metastases

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Bevacizumab
Sponsor:AstraZeneca AB

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Narcolepsy+1

Recruiting

Long-Term Study on the Safety and Effects of ALKS 2680 for Patients with Narcolepsy Type 1 and Type 2

Investigational

Long-Term Study on the Safety and Effects of ALKS 2680 for Patients with Narcolepsy Type 1 and Type 2

Investigational

The Netherlands

Participants:18–64 years · 65+ years
Substances:Alks 2680
Sponsor:Alkermes Inc.

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Acute myeloid leukaemia

Recruiting

Study on Ivosidenib, Azacitidine, and Venetoclax for Adults with Newly Diagnosed IDH1-Mutated Acute Myeloid Leukemia Ineligible for Intensive Chemotherapy

Registered drug

Study on Ivosidenib, Azacitidine, and Venetoclax for Adults with Newly Diagnosed IDH1-Mutated Acute Myeloid Leukemia Ineligible for Intensive Chemotherapy

Registered drug

The Netherlands

Participants:18–64 years · 65+ years
Substances:Azacitidine
Sponsor:Hemato-Oncologie voor Volwassenen Nederland (Hovon) Stichting

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Chronic lymphocytic leukaemia+1

Recruiting

Study on Venetoclax, Obinutuzumab, and Pirtobrutinib for Patients with Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Registered drugNo placebo

Study on Venetoclax, Obinutuzumab, and Pirtobrutinib for Patients with Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Registered drugNo placebo

The Netherlands

Participants:18–64 years · 65+ years
Substances:Obinutuzumab
Sponsor:University Of Cologne

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Clinical research in Zwolle

What the registry says about research in the country

01 Oncology Research

Innovative clinical trials exploring treatments for colorectal cancer, non-small cell lung cancer, and acute myeloid leukemia. Studies focus on evaluating novel drug combinations and targeted therapies to improve patient outcomes.

Advanced cancer treatments
Targeted therapy combinations
Immunotherapy research

Several trials investigating new approaches for melanoma and prostate cancer management.

02 Cardiovascular Studies

Research focusing on heart failure prevention and cardiovascular disease management. Trials evaluating new drug combinations including baxdrostat and dapagliflozin for improved cardiac outcomes.

Heart failure prevention
Cardiovascular risk reduction
Novel therapeutic approaches

Emphasis on preventive strategies and innovative treatment combinations.

03 Neurological Disorders

Clinical investigations into narcolepsy and Alzheimer's disease treatments. Studies evaluating new therapeutic options for Dravet Syndrome and various neurological conditions.

Sleep disorders
Cognitive function
Seizure management

Focus on improving quality of life and symptom management for patients.

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