University Hospital Bratislava

At University Hospital Bratislava, clinical trials in cardiovascular diseases focus on major conditions such as atherosclerotic cardiovascular disease, heart failure, and hypertension. These studies are designed to test new ways to lower cardiovascular risk, prevent serious events, and improve long-term heart health.

• Studies on atherosclerotic cardiovascular disease and prevention of major heart attacks and strokes
• Research in heart failure and related kidney complications
• Trials in hypertension and broader cardiovascular risk reduction

This research helps evaluate whether emerging therapies can better protect patients with established heart disease or those at high risk of future events.

The site conducts important studies in nervous system diseases and mental disorders, especially multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. The main goal is to improve symptom control, slow disease activity, and support better daily functioning for people living with chronic neurological conditions.

• Multiple sclerosis research focused on relapse control and long-term disease management
• Parkinson’s disease trials aimed at improving motor symptoms and treatment stability
• Alzheimer’s disease studies addressing agitation, psychosis, and cognitive decline

This area reflects a strong interest in both disease-modifying therapies and treatments that improve quality of life for patients and caregivers.

The clinical research portfolio includes neoplasms and hemic and lymphatic diseases, with trials in non-small cell lung cancer, multiple myeloma, acute lymphoblastic leukemia, and other advanced cancers. These studies aim to test new cancer treatments, compare them with current standards, and improve outcomes for patients with difficult-to-treat disease.

• Non-small cell lung cancer studies in locally advanced, metastatic, and biomarker-defined disease
• Multiple myeloma and leukemia research for relapsed or newly diagnosed blood cancers
• Trials exploring better treatment effectiveness and survival outcomes in advanced malignancies

This work supports the development of more effective cancer therapies and broader access to innovative oncology care.

A significant part of the research at this hospital centers on immune system diseases and nutritional and metabolic diseases, particularly IgA nephropathy, chronic kidney disease, and related inflammatory conditions. These trials are mainly designed to preserve kidney function, reduce protein loss in urine, and improve disease control in immune-driven disorders.

• IgA nephropathy and other glomerular diseases affecting kidney health
• Chronic kidney disease studies looking at progression and proteinuria
• Immune-targeted research in diseases driven by abnormal inflammation and antibody activity

The focus is on finding therapies that may slow progression and offer better long-term protection for kidney patients.

Clinical trials in eye diseases at University Hospital Bratislava include diabetic macular edema, neovascular age-related macular degeneration, and thyroid eye disease. These studies are intended to improve vision outcomes, reduce disease-related damage, and assess new approaches for chronic eye conditions.

• Diabetic macular edema and diabetic eye disease linked to diabetes
• Wet age-related macular degeneration and other retinal disorders
• Thyroid eye disease research focused on reducing swelling and eye protrusion

This field combines treatment evaluation with efforts to preserve sight and improve everyday visual function.

The site also participates in trials across respiratory tract diseases, musculoskeletal diseases, and selected congenital and hereditary disorders. Research includes conditions such as chronic obstructive pulmonary disease, viral lung infections, bullous pemphigoid, and hidradenitis suppurativa, with the aim of improving treatment effectiveness and symptom relief.

• Chronic obstructive pulmonary disease and severe viral lung infection studies
• Bullous pemphigoid and hidradenitis suppurativa research in inflammatory skin disease
• Trials in less common disorders such as multifocal motor neuropathy, hypophosphatasia, and spasticity

These studies show a broad interest in both common chronic illnesses and rarer conditions that still need better treatment options.

Additional trials address digestive system diseases, nutritional and metabolic diseases, and psychiatry and psychology. Key areas include non-alcoholic steatohepatitis, obesity, and symptoms linked to Alzheimer’s disease, such as agitation and psychosis, reflecting a strong interest in both physical and behavioral health.

• Non-alcoholic steatohepatitis and liver-related disease progression
• Overweight and obesity research tied to cardiovascular and metabolic risk
• Psychiatric symptoms in Alzheimer’s disease, including agitation and psychosis

These trials aim to improve disease management across interconnected metabolic, liver, and mental health conditions.