University Hospitals Pitie Salpetriere Charles Foix

At University Hospitals Pitie Salpetriere Charles Foix, the Medical Oncology program is strongly focused on neoplasms, with trials exploring new ways to treat acute myeloid leukaemia, multiple myeloma, follicular lymphoma, diffuse large B-cell lymphoma, and metastatic breast cancer. These studies are designed to test more effective cancer therapies, compare treatment options, and improve outcomes for patients with advanced or relapsed disease.

• Testing new treatment strategies for acute myeloid leukaemia and multiple myeloma
• Evaluating therapies for lymphoma and other blood cancers
• Assessing novel approaches for breast cancer and other advanced solid tumors

This research also includes studies aimed at improving disease control after prior treatment, helping define better options for patients with hard-to-treat cancers.

The site is active in cardiovascular diseases and nutritional and metabolic diseases, with trials in atherosclerotic cardiovascular disease, non-obstructive coronary artery disease, STEMI, and severe hypertriglyceridemia. Research here focuses on preventing heart events, reducing plaque burden, and improving blood lipid control through better therapies.

• Studying treatments for atherosclerotic cardiovascular disease and coronary artery disease
• Evaluating emergency care approaches for acute heart attack
• Testing therapies to lower triglycerides and reduce metabolic risk

These trials aim to improve long-term cardiovascular health and support earlier, more effective intervention in high-risk patients.

Clinical trials at this Paris site also cover digestive system diseases and virus diseases, including chronic hepatitis D infection, non-alcoholic steatohepatitis, locoregional hepatocellular carcinoma, and squamous carcinoma of the anal canal. The main goal is to evaluate treatments that may slow liver damage, control cancer growth, and improve disease-related symptoms.

• Investigating therapies for chronic liver disease and hepatitis D
• Assessing treatment options for NASH and hepatocellular carcinoma
• Exploring new approaches for anal cancer and related digestive cancers

Several studies are designed to measure whether these treatments can better protect liver function and delay disease progression.

The research portfolio includes nervous system diseases, with studies in Alzheimer’s disease and seizure disorders. These trials are focused on improving symptom control, slowing cognitive decline, and finding more effective options for patients living with progressive neurological conditions.

• Evaluating treatments for early Alzheimer’s disease and prodromal cognitive decline
• Studying medicines that may help preserve memory and function
• Assessing therapies for seizure episodes and rapid symptom relief

This area reflects a broader effort to improve both daily functioning and long-term outcomes in neurological illness.

Trials in immune system diseases and musculoskeletal diseases include psoriatic arthritis, rheumatoid arthritis, and high-risk acute graft versus host disease. The research is centered on finding safer and more effective ways to control inflammation, reduce immune-related complications, and improve quality of life.

• Testing therapies for psoriatic arthritis and rheumatoid arthritis
• Evaluating treatment options for acute graft versus host disease
• Exploring better control of immune-mediated inflammation

These studies support ongoing progress in managing chronic inflammatory disease and complex post-transplant immune problems.

The site also participates in trials for respiratory tract diseases and virus diseases, including nontuberculous mycobacterial lung infection and other chronic lung infections. The purpose of this research is to improve respiratory symptom relief, infection control, and overall lung health in patients with difficult-to-treat disease.

• Studying treatment approaches for NTM lung infection
• Assessing ways to improve respiratory symptoms and infection outcomes
• Supporting better care for patients with persistent lung disease

This work adds important insight into managing infections that often require long-term and specialized treatment.

Research at University Hospitals Pitie Salpetriere Charles Foix extends to congenital, hereditary, and neonatal diseases and abnormalities, with trials in FKRP-related limb-girdle muscular dystrophy and other rare inherited conditions. These studies are intended to assess new therapies that may improve muscle function, disease stability, and patient independence.

• Evaluating treatment options for limb-girdle muscular dystrophy
• Studying therapies for genetic muscle disease
• Exploring approaches that may support mobility and daily function

The focus on rare disease research highlights the center’s role in advancing care where treatment options are often limited.