Skip to content
Clinical Trials – home

Rare diseases

Investigational molecules

Locations

Our offerNewsroom

Not yet recruiting

Study of ropivacaine, sodium chloride and gadoteric acid in nerve blocks for hip pain in healthy volunteers

Verified siteRegistered drug
Clinical Trials Concierge

Prefer not to search? Our Concierge searches the trials for you.

What is this trial about?

A plain-language summary of the goals, design and what participants do

This study focuses on investigating nerve blocks for hip pain management. The research compares two different types of nerve blocks: the subpectineal obturator nerve blockade (SOB) and suprainguinal fascia iliaca compartment block (SIFICB). These procedures involve injecting medications near specific nerves to provide pain relief in the hip area.

The medications used in this study include Ropivacaine, which is a local anesthetic solution for injection, and Dotarem, a contrast agent used for imaging. Sodium chloride solution is also used during the procedure. The purpose of the study is to determine how effectively these nerve blocks can reduce sensation in specific nerves, particularly the obturator nerve.

During the study, participants will receive nerve blocks and undergo various tests to measure the effectiveness of the treatment. These tests include muscle strength measurements and special imaging called MRI to see how the medication spreads in the body. The study will evaluate how well the nerve blocks work by measuring changes in muscle activity and areas of numbness in the skin.

The research process

The trial runs in 5 steps – from screening to follow-up. Each step says what happens and what the team monitors.

  1. Step 1

    Initial nerve block procedure

    You will receive one of two types of nerve blocks: either a suprainguinal fascia iliaca compartment block (SIFICB) or a subpectineal obturator nerve blockade (SOB)

    The procedure involves an injection of Ropivacain (local anesthetic) and sodium chloride solution in the hip area

    The injection will be administered through the skin to target specific nerve areas

  2. Step 2

    Muscle response testing

    Your muscle responses will be measured using EMG (a test that records electrical signals from muscles)

    The test focuses on the gracilis muscle (inner thigh muscle)

    Measurements will be taken before and after the nerve block to compare the differences

  3. Step 3

    Imaging procedure

    You will undergo an MRI scan using Dotarem (contrast agent)

    The imaging will show how the medication spreads in the targeted area

    This procedure helps to verify the placement and distribution of the nerve block

  4. Step 4

    Strength assessment

    Your muscle strength will be measured using a special device called a dynamometer

    The test will focus on your thigh muscles (adductor and quadriceps)

    The measurements will help determine how the nerve block affects muscle function

  5. Step 5

    Skin sensation testing

    Your skin sensation will be tested in the affected area

    The test will determine where the numbness occurs

    The size of the numb area will be measured and documented

Who can join the trial?

7 criteria

  • Patient must be 18 years or older
  • Patient must have a BMI (Body Mass Index) less than 25 kg/m² - BMI is a measure that uses your height and weight to determine if your weight is healthy
  • Patient must weigh 69 kilograms or more
  • Patient must be classified as ASA I or II - this means being healthy or having only mild systemic disease according to the American Society of Anesthesiologists classification system
  • Patient must be able to read and understand Danish
  • Patient must be able to read, understand and sign the informed consent form
  • Both male and female participants can join the study

Who cannot join the trial?

15 criteria

  • Body Mass Index (BMI) over 35 (severe obesity)
  • Known allergies to local anesthetic medications
  • History of blood clotting disorders or current use of blood thinners
  • Active infection in the hip or groin area
  • Previous surgery in the hip region
  • Neurological conditions affecting the hip or leg
  • Pregnancy or breastfeeding
  • Inability to provide informed consent
  • Current participation in other clinical trials
  • Chronic pain conditions requiring regular pain medication
  • Uncontrolled high blood pressure
  • Severe heart, liver, or kidney disease
  • History of adverse reactions to medical procedures
  • Mental health conditions that could affect study participation
  • Use of medications that could interact with the study procedures
Clinical Trials Concierge

Prefer not to search? Our Concierge searches the trials for you.

Tell us about your condition – we search every trial in Europe and connect you with the right site.

We usually reply within a few days

Verified sites

All sites with verified contact details – recruitment status may not be available; ask directly

Trial locations

Where you can join this trial

Countries are shaded by recruitment status. Click a recruiting country to ask about joining there.

Not yet recruiting
Not finding your country?

Not sure what to do next?

Joining a clinical trial can seem overwhelming. We guide you step by step, so you know exactly what to expect and how we support you through the process.

See the full process and FAQ

Investigated drugs

Suprainguinal fascia iliaca compartment block (SIFICB) is a type of local anesthetic nerve block technique where medication is injected into a specific anatomical space above the groin area. This technique aims to provide pain relief by blocking several nerves that supply sensation to the hip and thigh region. Subpectineal obturator nerve block (SOB) is another type of local anesthetic nerve block that specifically targets the obturator nerve, which provides sensation to parts of the thigh and hip joint. The medication is injected near the obturator nerve as it passes through the pectineal muscle. Note: While the specific local anesthetic medication used in these nerve blocks is not mentioned in the source data, these procedures typically use local anesthetic medications to temporarily block nerve signals in the targeted areas.

What is already known about the treatment

Based on the clinical trial data provided, no specific medications are mentioned in the source material. The trial appears to be focused on comparing two nerve block techniques (SIFICB and SOB) rather than testing specific medications. Without information about particular medications used in the trial, I cannot provide medication descriptions in the requested format. If you would like medication descriptions for the local anesthetics typically used in nerve blocks like these, please provide that specific information, and I will format it according to your requirements.

Investigated diseases

Hip Pain - A condition characterized by discomfort, aching, or soreness in or around the hip joint. The pain can develop gradually or suddenly, affecting the ability to walk, climb stairs, or perform daily activities. Hip pain may be felt in various areas around the hip joint, including the thigh, groin, or buttocks. The condition can range from mild to severe and may be accompanied by stiffness, reduced range of motion, or weakness in the affected area. Hip pain can affect people of all ages and may result from various underlying causes.
Trial detailsLast updated 7 Oct 2026
Age18+ yearsPhasePhase IITrial ID2023-510388-37-00Protocol codeSIFICBEstimated enrolment20 patientsSponsorRegion Midtjylland

sourced from the EU Clinical Trials Register and site verification

Want to learn more about this trial or check if you can participate?

Clinical Trials Concierge

Prefer not to search? Our Concierge searches the trials for you.

Tell us about your condition – we search every trial in Europe and connect you with the right site.