In short

Essential hypertension, also known as primary hypertension, is a common condition where blood pressure remains consistently high without an identifiable cause. Currently, there is 1 ongoing clinical trial exploring how different blood pressure medications work and how treatment can be personalized based on individual biological markers. This trial is being conducted in the Netherlands and aims to help doctors better predict which medications will work best for each patient.

Clinical trial locations

Netherlands
- Study on Predicting Blood Pressure Response in Hypertension Patients Using Amlodipine, Olmesartan Medoxomil, Hydrochlorothiazide, and Drug Combination

Study on Predicting Blood Pressure Response in Hypertension Patients Using Amlodipine, Olmesartan Medoxomil, Hydrochlorothiazide, and Drug Combination

This clinical trial is investigating how well different blood pressure medications work in people with primary hypertension. The study is particularly focused on finding biological markers that can help predict which medication will be most effective for each individual patient.

Who can participate:

Adults between 18 and 75 years old
People with grade 1-2 hypertension, meaning their 24-hour systolic blood pressure (the top number) is between 130 and 164
Those not currently taking blood pressure medication, or those willing to stop their single blood pressure medication for 4 weeks before joining
People who need blood pressure treatment according to current medical guidelines
Women who are not breastfeeding and are not at risk of becoming pregnant during the study (either through menopause, surgical procedures, or reliable birth control methods)

Who cannot participate:

People whose high blood pressure has a known specific cause (not primary hypertension)
Those outside the specified age range
Vulnerable populations requiring special protection
People who do not meet other specific study requirements

What the trial involves:

The study tests four different treatment approaches to lowering blood pressure. Participants will be assigned to take one of the following medications for four weeks:

Amlodipine (10 mg daily) – a medication that relaxes and widens blood vessels
Olmesartan medoxomil (40 mg daily) – a medication that blocks substances that tighten blood vessels
Hydrochlorothiazide (25 mg daily) – a "water pill" that helps remove excess salt and water from the body
Olmesartan/Amlodipine combination (20 mg/5 mg daily) – a combination that works in two ways to lower blood pressure

All medications are taken orally as tablets. Throughout the study, participants will have their blood pressure monitored over 24-hour periods to see how well the medication works both during the day and at night. Researchers will also collect blood and urine samples to create biomarker profiles.

Main goals:

The primary aim is to identify specific biological markers (called MOMICs) that can predict how a person's blood pressure will respond to these treatments. The study will also examine how these markers relate to nighttime blood pressure changes and any side effects that occur. This research could lead to more personalized treatment plans, ensuring people receive the most effective medication for their individual condition.

The trial is expected to be completed by October 2025.

Summary

There is currently one active clinical trial for essential hypertension, taking place in the Netherlands. This trial represents an important step toward personalized medicine for high blood pressure treatment. Rather than using a trial-and-error approach to finding the right medication, this research aims to identify biological markers that can predict which blood pressure medication will work best for each patient.

The study examines four different medication approaches, including three individual drugs (amlodipine, olmesartan medoxomil, and hydrochlorothiazide) and one combination therapy. All of these are established medications for treating high blood pressure, but this trial seeks to understand the biological reasons why they work better for some people than others.

This research is particularly notable because it focuses on a practical question that affects millions of people: how to choose the right blood pressure medication from the start, rather than trying multiple medications over months or years. The results could help doctors make more informed treatment decisions based on individual patient characteristics.

Essential hypertension Trials in Disease

Clinical trials for Essential hypertension