Knee arthroplasty Trials in Disease

Study on Magnesium Sulfate and Ropivacaine for Pain Relief in Knee Replacement Surgery Patients

This clinical trial is investigating whether adding magnesium sulfate to a standard nerve block can provide longer-lasting pain relief for patients undergoing total knee replacement surgery. The study focuses on enhancing pain management during the recovery period following this common surgical procedure.

Main inclusion criteria: This trial is open to adults between 18 and 80 years old who are scheduled for total knee replacement surgery due to knee joint wear and tear. Participants must be in reasonable health, classified as ASA I, II, or III health status, which indicates they are healthy enough to undergo surgery safely. Both men and women are eligible to participate, and all participants must provide informed consent, meaning they understand the study and agree to take part.

Main exclusion criteria: Patients who are not having total knee replacement surgery cannot participate. Those who fall outside the 18 to 80 age range are also excluded. Additionally, patients considered part of vulnerable populations cannot join this study.

Focus and goal: The primary goal of this trial is to determine if magnesium sulfate can extend the duration of pain relief provided by a nerve block during knee replacement surgery. The nerve block is performed using ropivacaine hydrochloride, a local anesthetic that numbs the area around the knee. Researchers will monitor how long it takes for patients to request additional pain medication after receiving the nerve block, which helps them understand whether the combination offers better pain control than the standard treatment alone. This study aims to provide valuable information that could lead to improved recovery experiences for patients undergoing knee replacement surgery.

Investigational drugs: The trial uses two main medications. Magnesium sulfate is being studied as an additional treatment to help the main pain relief medication work better and last longer. It is administered as an injection near the nerves in the adductor canal during surgery. At the molecular level, magnesium sulfate is thought to work by blocking certain signals in the nervous system that are responsible for pain. Ropivacaine is the primary anesthetic used to numb the area around the knee during surgery. It helps block pain signals from reaching the brain, allowing patients to feel less pain during and after the procedure. The trial is testing how well these two medications work together to provide extended pain relief.